KANSL1
Summary: This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| KAT8 regulatory NSL complex subunit 1 | MIM:612452 | Ensembl:ENSG00000120071 | HGNC:HGNC:24565 | PA142671604 | 17q21.31 |
Gene Categories:
HISTONE MODIFICATIONGO terms in KANSL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0035035 | histone acetyltransferase binding |
| MF | IBA | GO:0043995 | histone acetyltransferase activity (H4-K5 specific) |
| MF | IDA | GO:0043995 | histone acetyltransferase activity (H4-K5 specific) |
| MF | IBA | GO:0043996 | histone acetyltransferase activity (H4-K8 specific) |
| MF | IDA | GO:0043996 | histone acetyltransferase activity (H4-K8 specific) |
| MF | IBA | GO:0046972 | histone acetyltransferase activity (H4-K16 specific) |
| MF | IDA | GO:0046972 | histone acetyltransferase activity (H4-K16 specific) |
| BP | IDA | GO:0043981 | histone H4-K5 acetylation |
| BP | IDA | GO:0043982 | histone H4-K8 acetylation |
| BP | IDA | GO:0043984 | histone H4-K16 acetylation |
| CC | IDA | GO:0000123 | histone acetyltransferase complex |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0044545 | NSL complex |
| CC | IDA | GO:0071339 | MLL1 complex |
Gene expression in normal tissue: KANSL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KANSL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KANSL1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.