KANSL1
Summary: This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
KAT8 regulatory NSL complex subunit 1 | MIM:612452 | Ensembl:ENSG00000120071 | HGNC:HGNC:24565 | PA142671604 | 17q21.31 |
Gene Categories:
HISTONE MODIFICATIONGO terms in KANSL1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0035035 | histone acetyltransferase binding |
MF | IBA | GO:0043995 | histone acetyltransferase activity (H4-K5 specific) |
MF | IDA | GO:0043995 | histone acetyltransferase activity (H4-K5 specific) |
MF | IBA | GO:0043996 | histone acetyltransferase activity (H4-K8 specific) |
MF | IDA | GO:0043996 | histone acetyltransferase activity (H4-K8 specific) |
MF | IBA | GO:0046972 | histone acetyltransferase activity (H4-K16 specific) |
MF | IDA | GO:0046972 | histone acetyltransferase activity (H4-K16 specific) |
BP | IDA | GO:0043981 | histone H4-K5 acetylation |
BP | IDA | GO:0043982 | histone H4-K8 acetylation |
BP | IDA | GO:0043984 | histone H4-K16 acetylation |
CC | IDA | GO:0000123 | histone acetyltransferase complex |
CC | IEA | GO:0000777 | condensed chromosome kinetochore |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IBA | GO:0044545 | NSL complex |
CC | IDA | GO:0071339 | MLL1 complex |
Gene expression in normal tissue: KANSL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KANSL1
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
reactome | R-HSA-3214847 | HATs acetylate histones |
reactome | R-HSA-3247509 | Chromatin modifying enzymes |
reactome | R-HSA-4839726 | Chromatin organization |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in KANSL1