KANSL1


Summary: This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
KAT8 regulatory NSL complex subunit 1MIM:612452Ensembl:ENSG00000120071HGNC:HGNC:24565PA14267160417q21.31

Gene Categories:

HISTONE MODIFICATION

GO terms in KANSL1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0035035histone acetyltransferase binding
MFIBAGO:0043995histone acetyltransferase activity (H4-K5 specific)
MFIDAGO:0043995histone acetyltransferase activity (H4-K5 specific)
MFIBAGO:0043996histone acetyltransferase activity (H4-K8 specific)
MFIDAGO:0043996histone acetyltransferase activity (H4-K8 specific)
MFIBAGO:0046972histone acetyltransferase activity (H4-K16 specific)
MFIDAGO:0046972histone acetyltransferase activity (H4-K16 specific)
BPIDAGO:0043981histone H4-K5 acetylation
BPIDAGO:0043982histone H4-K8 acetylation
BPIDAGO:0043984histone H4-K16 acetylation
CCIDAGO:0000123histone acetyltransferase complex
CCIEAGO:0000777condensed chromosome kinetochore
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0044545NSL complex
CCIDAGO:0071339MLL1 complex

Gene expression in normal tissue: KANSL1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KANSL1


DatabasePathway IDPathway Des.
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KANSL1

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