KAT6A
Summary: This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine acetyltransferase 6A | MIM:601408 | Ensembl:ENSG00000083168 | HGNC:HGNC:13013 | PA37592 | 8p11.21 |
GO terms in KAT6A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0004402 | histone acetyltransferase activity |
| MF | IDA | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0010485 | H4 histone acetyltransferase activity |
| MF | IDA | GO:0016407 | acetyltransferase activity |
| MF | TAS | GO:0016407 | acetyltransferase activity |
| MF | IBA | GO:0042393 | histone binding |
| BP | TAS | GO:0006323 | DNA packaging |
| BP | IEA | GO:0006334 | nucleosome assembly |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006473 | protein acetylation |
| BP | IDA | GO:0016573 | histone acetylation |
| BP | IDA | GO:0030099 | myeloid cell differentiation |
| BP | IBA | GO:0043966 | histone H3 acetylation |
| BP | IDA | GO:0043966 | histone H3 acetylation |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0090398 | cellular senescence |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| CC | IBA | GO:0000123 | histone acetyltransferase complex |
| CC | IEA | GO:0000786 | nucleosome |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016605 | PML body |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IBA | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex |
| CC | IBA | GO:0070776 | MOZ/MORF histone acetyltransferase complex |
| CC | IDA | GO:0070776 | MOZ/MORF histone acetyltransferase complex |
Gene expression in normal tissue: KAT6A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KAT6A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804758 | Regulation of TP53 Activity through Acetylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 4 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD42 | Vorinostat | 5 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD64 | Parbendazole | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KAT6A
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.