KCNB1
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily B member 1 | MIM:600397 | Ensembl:ENSG00000158445 | HGNC:HGNC:6231 | PA209 | 20q13.13 |
GO terms in KCNB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001508 | action potential |
| BP | ISS | GO:0006904 | vesicle docking involved in exocytosis |
| BP | ISS | GO:0007215 | glutamate receptor signaling pathway |
| BP | ISS | GO:0010701 | positive regulation of norepinephrine secretion |
| BP | ISS | GO:0031669 | cellular response to nutrient levels |
| BP | ISS | GO:0033605 | positive regulation of catecholamine secretion |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | ISS | GO:0045956 | positive regulation of calcium ion-dependent exocytosis |
| BP | ISS | GO:0046676 | negative regulation of insulin secretion |
| BP | TAS | GO:0050796 | regulation of insulin secretion |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | ISS | GO:0071333 | cellular response to glucose stimulus |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IDA | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0072659 | protein localization to plasma membrane |
| BP | IDA | GO:0090314 | positive regulation of protein targeting to membrane |
| BP | ISS | GO:0090314 | positive regulation of protein targeting to membrane |
| BP | ISS | GO:0098900 | regulation of action potential |
| BP | ISS | GO:1900454 | positive regulation of long term synaptic depression |
| BP | ISS | GO:2000671 | regulation of motor neuron apoptotic process |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IDA | GO:0008076 | voltage-gated potassium channel complex |
| CC | ISS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016328 | lateral plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0030424 | axon |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IBA | GO:0032590 | dendrite membrane |
| CC | IBA | GO:0032809 | neuronal cell body membrane |
| CC | ISS | GO:0032809 | neuronal cell body membrane |
| CC | IEA | GO:0042383 | sarcolemma |
| CC | ISS | GO:0043204 | perikaryon |
| CC | IBA | GO:0045211 | postsynaptic membrane |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
| MF | IBA | GO:0005251 | delayed rectifier potassium channel activity |
| MF | IDA | GO:0005251 | delayed rectifier potassium channel activity |
| MF | ISS | GO:0005251 | delayed rectifier potassium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | ISS | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: KCNB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNB1
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