KCNC1
Summary: This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily C member 1 | MIM:176258 | Ensembl:ENSG00000129159 | HGNC:HGNC:6233 | PA30026 | 11p15.1 |
GO terms in KCNC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
| MF | TAS | GO:0005249 | voltage-gated potassium channel activity |
| MF | IBA | GO:0005251 | delayed rectifier potassium channel activity |
| MF | ISS | GO:0005251 | delayed rectifier potassium channel activity |
| MF | IEA | GO:0019894 | kinesin binding |
| MF | IEA | GO:0044325 | ion channel binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IDA | GO:0008076 | voltage-gated potassium channel complex |
| CC | ISS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IEA | GO:0009986 | cell surface |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0030424 | axon |
| CC | IEA | GO:0030673 | axolemma |
| CC | IBA | GO:0032590 | dendrite membrane |
| CC | IEA | GO:0032590 | dendrite membrane |
| CC | IBA | GO:0032809 | neuronal cell body membrane |
| CC | ISS | GO:0032809 | neuronal cell body membrane |
| CC | IBA | GO:0043025 | neuronal cell body |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0009642 | response to light intensity |
| BP | IEA | GO:0010996 | response to auditory stimulus |
| BP | IEA | GO:0014075 | response to amine |
| BP | IEA | GO:0021549 | cerebellum development |
| BP | IEA | GO:0021759 | globus pallidus development |
| BP | IEA | GO:0035690 | cellular response to drug |
| BP | IEA | GO:0035864 | response to potassium ion |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | IDA | GO:0051262 | protein tetramerization |
| BP | IEA | GO:0071774 | response to fibroblast growth factor |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0071805 | potassium ion transmembrane transport |
| BP | IEA | GO:1903818 | positive regulation of voltage-gated potassium channel activity |
| BP | IEA | GO:1990089 | response to nerve growth factor |
Gene expression in normal tissue: KCNC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNC1
CLASSFICATION
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