KCNH7
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
potassium voltage-gated channel subfamily H member 7 | MIM:608169 | Ensembl:ENSG00000184611 | HGNC:HGNC:18863 | PA38723 | 2q24.2 |
GO terms in KCNH7
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
BP | IBA | GO:0042391 | regulation of membrane potential |
BP | IBA | GO:0071805 | potassium ion transmembrane transport |
BP | IEA | GO:0071805 | potassium ion transmembrane transport |
CC | TAS | GO:0005886 | plasma membrane |
CC | IBA | GO:0005887 | integral component of plasma membrane |
MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
Gene expression in normal tissue: KCNH7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNH7
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-112316 | Neuronal System |
reactome | R-HSA-1296071 | Potassium Channels |
reactome | R-HSA-1296072 | Voltage gated Potassium channels |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNH7