KCNJ4
Summary: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily J member 4 | MIM:600504 | Ensembl:ENSG00000168135 | HGNC:HGNC:6265 | PA30048 | 22q13.1 |
GO terms in KCNJ4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005242 | inward rectifier potassium channel activity |
| MF | TAS | GO:0005242 | inward rectifier potassium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015467 | G-protein activated inward rectifier potassium channel activity |
| MF | IPI | GO:0030165 | PDZ domain binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | IBA | GO:0010107 | potassium ion import |
| BP | IBA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
Gene expression in normal tissue: KCNJ4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNJ4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| pharmgkb | PA2033 | Antiarrhythmic Pathway, Pharmacodynamics |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296041 | Activation of G protein gated Potassium channels |
| reactome | R-HSA-1296053 | Classical Kir channels |
| reactome | R-HSA-1296059 | G protein gated Potassium channels |
| reactome | R-HSA-1296065 | Inwardly rectifying K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576886 | Phase 4 - resting membrane potential |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-977443 | GABA receptor activation |
| reactome | R-HSA-977444 | GABA B receptor activation |
| reactome | R-HSA-991365 | Activation of GABAB receptors |
| reactome | R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNJ4
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.