Summary: This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015].

potassium voltage-gated channel subfamily J member 6MIM:600877Ensembl:ENSG00000157542HGNC:HGNC:6267PA3004921q22.13

GO terms in KCNJ6

Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005794Golgi apparatus
CCHDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0008076voltage-gated potassium channel complex
BPTASGO:0006813potassium ion transport
BPIBAGO:0010107potassium ion import
BPIBAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0034765regulation of ion transmembrane transport
MFIBAGO:0005242inward rectifier potassium channel activity
MFTASGO:0005242inward rectifier potassium channel activity
MFIPIGO:0005515protein binding
MFTASGO:0015467G-protein activated inward rectifier potassium channel activity

Gene expression in normal tissue: KCNJ6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNJ6

DatabasePathway IDPathway Des.
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296041Activation of G protein gated Potassium channels
reactomeR-HSA-1296059G protein gated Potassium channels
reactomeR-HSA-1296065Inwardly rectifying K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-977443GABA receptor activation
reactomeR-HSA-977444GABA B receptor activation
reactomeR-HSA-991365Activation of GABAB receptors
reactomeR-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNJ6