KIAA1324
Summary: Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| KIAA1324 | MIM:611298 | Ensembl:ENSG00000116299 | HGNC:HGNC:29618 | PA142671607 | 1p13.3 |
GO terms in KIAA1324
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000045 | autophagosome assembly |
| BP | IMP | GO:0009267 | cellular response to starvation |
| BP | IMP | GO:0044090 | positive regulation of vacuole organization |
| BP | IMP | GO:2000786 | positive regulation of autophagosome assembly |
| CC | IDA | GO:0005764 | lysosome |
| CC | IEA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005770 | late endosome |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0031902 | late endosome membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | HDA | GO:0003723 | RNA binding |
Gene expression in normal tissue: KIAA1324
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIAA1324
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KIAA1324
CLASSFICATION
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