KIAA1549


Summary: The protein encoded by this gene belongs to the UPF0606 family. This gene has been found to be fused to the BRAF oncogene in many cases of pilocytic astrocytoma. The fusion results from 2Mb tandem duplications at 7q34. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:613344
PHARMGKB IDPA162393138
Map Location7q34

GO terms in KIAA1549


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
CC TAS GO:0005886 plasma membrane
CC IEA GO:0016021 integral component of membrane
BP IEA GO:0006357 regulation of transcription by RNA polymerase II
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Gene expression in normal tissue: KIAA1549

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined34Ferroptosis2DNA replication2Apoptosis regulation2PI3K/MTOR signaling1Drug metabolism - cytochrome P4501Stilbenoid, diarylheptanoid and gingerol biosynthesis1Cell cycle1Chromatin histone acetylation1ERK MAPK signaling1

Pathways in KIAA1549


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1643685 Disease
reactome R-HSA-5663202 Diseases of signal transduction
reactome R-HSA-6802952 Signaling by BRAF and RAF fusions
reactome R-HSA-6802957 Oncogenic MAPK signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD679 Bistramide A 1
iGMDRD280 CYTOCHALASIN B 2
iGMDRD152 179324-69-7 2
iGMDRD193 Fqi1 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

17undefined2BCL2L21MTOR1TERT1WEE11NEDD8-activating enzyme1PLK11RARA1TOP2B1PRKCA

Gene Structure: PDB

Models in KIAA1549

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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