KIF24


Summary: This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kinesin family member 24MIM:613747Ensembl:ENSG00000186638HGNC:HGNC:19916PA1426715899p13.3

GO terms in KIF24


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0007018microtubule-based movement
BPIDAGO:0007019microtubule depolymerization
BPIMPGO:0060271cilium assembly
BPTASGO:0097711ciliary basal body-plasma membrane docking
CCIDAGO:0005814centriole
CCTASGO:0005829cytosol
CCIBAGO:0005871kinesin complex
CCIBAGO:0005874microtubule
CCIEAGO:0005874microtubule
CCIDAGO:0032991protein-containing complex
MFIBAGO:0003777microtubule motor activity
MFIDAGO:0003777microtubule motor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008017microtubule binding
MFIEAGO:0008017microtubule binding
MFIBAGO:0016887ATPase activity
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: KIF24

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KIF24


DatabasePathway IDPathway Des.
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KIF24

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