KIF24
Summary: This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kinesin family member 24 | MIM:613747 | Ensembl:ENSG00000186638 | HGNC:HGNC:19916 | PA142671589 | 9p13.3 |
GO terms in KIF24
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007018 | microtubule-based movement |
| BP | IDA | GO:0007019 | microtubule depolymerization |
| BP | IMP | GO:0060271 | cilium assembly |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| CC | IDA | GO:0005814 | centriole |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005871 | kinesin complex |
| CC | IBA | GO:0005874 | microtubule |
| CC | IEA | GO:0005874 | microtubule |
| CC | IDA | GO:0032991 | protein-containing complex |
| MF | IBA | GO:0003777 | microtubule motor activity |
| MF | IDA | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IBA | GO:0016887 | ATPase activity |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: KIF24
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIF24
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KIF24
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