KIF2A
Summary: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kinesin family member 2A | MIM:602591 | Ensembl:ENSG00000068796 | HGNC:HGNC:6318 | PA162393356 | 5q12.1 |
GO terms in KIF2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003774 | motor activity |
| MF | IBA | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IBA | GO:0016887 | ATPase activity |
| BP | IGI | GO:0000226 | microtubule cytoskeleton organization |
| BP | TAS | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | IBA | GO:0007018 | microtubule-based movement |
| BP | TAS | GO:0007018 | microtubule-based movement |
| BP | TAS | GO:0007019 | microtubule depolymerization |
| BP | IDA | GO:0007052 | mitotic spindle organization |
| BP | IEA | GO:0007399 | nervous system development |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IGI | GO:0030334 | regulation of cell migration |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0090307 | mitotic spindle assembly |
| CC | IDA | GO:0000922 | spindle pole |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005814 | centriole |
| CC | IBA | GO:0005819 | spindle |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005871 | kinesin complex |
| CC | IBA | GO:0005874 | microtubule |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IEA | GO:0097228 | sperm principal piece |
| CC | IDA | GO:0120103 | centriolar subdistal appendage |
Gene expression in normal tissue: KIF2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIF2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-983189 | Kinesins |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| pid | plk1_pathway | PLK1 signaling events |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KIF2A
CLASSFICATION
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