Summary: The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].

kirre like nephrin family adhesion molecule 3MIM:607761Ensembl:ENSG00000149571HGNC:HGNC:23204PA13495828311q24.2

GO terms in KIRREL3

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001764neuron migration
BPIEAGO:0002121inter-male aggressive behavior
BPISSGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPISSGO:0007416synapse assembly
BPIEAGO:0021740principal sensory nucleus of trigeminal nerve development
BPISSGO:0021766hippocampus development
BPIEAGO:0048812neuron projection morphogenesis
BPIEAGO:0072102glomerulus morphogenesis
CCISSGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCISSGO:0016021integral component of membrane
CCIEAGO:0043198dendritic shaft
MFIPIGO:0005515protein binding

Gene expression in normal tissue: KIRREL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KIRREL3

DatabasePathway IDPathway Des.
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-373753Nephrin family interactions
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KIRREL3