KLF11
Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Kruppel like factor 11 | MIM:603301 | Ensembl:ENSG00000172059 | HGNC:HGNC:11811 | PA36518 | 2p25.1 |
GO terms in KLF11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IDA | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:1901653 | cellular response to peptide |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0016604 | nuclear body |
Gene expression in normal tissue: KLF11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLF11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLF11
CLASSFICATION
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