KLF4
Summary: This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Kruppel like factor 4 | MIM:602253 | Ensembl:ENSG00000136826 | HGNC:HGNC:6348 | PA30138 | 9q31.2 |
GO terms in KLF4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005719 | nuclear euchromatin |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0044798 | nuclear transcription factor complex |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007500 | mesodermal cell fate determination |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009913 | epidermal cell differentiation |
| BP | IGI | GO:0010628 | positive regulation of gene expression |
| BP | IGI | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0014740 | negative regulation of muscle hyperplasia |
| BP | IDA | GO:0016525 | negative regulation of angiogenesis |
| BP | ISS | GO:0019827 | stem cell population maintenance |
| BP | IEA | GO:0031077 | post-embryonic camera-type eye development |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0032270 | positive regulation of cellular protein metabolic process |
| BP | IDA | GO:0034115 | negative regulation of heterotypic cell-cell adhesion |
| BP | TAS | GO:0035019 | somatic stem cell population maintenance |
| BP | IMP | GO:0035166 | post-embryonic hemopoiesis |
| BP | IDA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity |
| BP | IDA | GO:0045415 | negative regulation of interleukin-8 biosynthetic process |
| BP | IMP | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | ISS | GO:0045595 | regulation of cell differentiation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046985 | positive regulation of hemoglobin biosynthetic process |
| BP | IEA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048679 | regulation of axon regeneration |
| BP | IEA | GO:0048730 | epidermis morphogenesis |
| BP | TAS | GO:0050728 | negative regulation of inflammatory response |
| BP | IGI | GO:0051247 | positive regulation of protein metabolic process |
| BP | IEA | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IDA | GO:0051973 | positive regulation of telomerase activity |
| BP | IEA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IDA | GO:0060761 | negative regulation of response to cytokine stimulus |
| BP | IDA | GO:0061614 | pri-miRNA transcription by RNA polymerase II |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IDA | GO:0071363 | cellular response to growth factor stimulus |
| BP | IEA | GO:0071409 | cellular response to cycloheximide |
| BP | IMP | GO:0071499 | cellular response to laminar fluid shear stress |
| BP | IDA | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | IEA | GO:1901653 | cellular response to peptide |
| BP | IGI | GO:1903672 | positive regulation of sprouting angiogenesis |
| BP | IEA | GO:1904798 | positive regulation of core promoter binding |
| BP | IGI | GO:1904998 | negative regulation of leukocyte adhesion to arterial endothelial cell |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| BP | IDA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| BP | IDA | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000987 | proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0001010 | transcription factor activity, sequence-specific DNA-binding transcription factor recruiting |
| MF | IMP | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | ISS | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IDA | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | IEA | GO:0001221 | transcription cofactor binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008013 | beta-catenin binding |
| MF | NAS | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0035014 | phosphatidylinositol 3-kinase regulator activity |
| MF | IEA | GO:0042826 | histone deacetylase binding |
| MF | ISS | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
Gene expression in normal tissue: KLF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLF4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1991 | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3299 | let-7 inhibition of ES cell reprogramming |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP3971 | Role of Osx and miRNAs in tooth development |
| wikipathways | WP4149 | White fat cell differentiation |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLF4
CLASSFICATION
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