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KLHDC3

Summary: The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
kelch domain containing 3	MIM:611248	Ensembl:ENSG00000124702	HGNC:HGNC:20704	PA134892782	6p21.1

GO terms in KLHDC3

Term Type	Evidence Type	GO Term ID	GO Des.
BP	NAS	GO:0007131	reciprocal meiotic recombination
BP	TAS	GO:0036498	IRE1-mediated unfolded protein response
CC	IBA	GO:0000790	nuclear chromatin
CC	IDA	GO:0000790	nuclear chromatin
CC	IDA	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
MF	IBA	GO:0003682	chromatin binding
MF	IDA	GO:0003682	chromatin binding
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: KLHDC3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLHDC3

Database	Pathway ID	Pathway Des.
wikipathways	WP3472	XBP1(S) activates chaperone genes
reactome	R-HSA-381038	XBP1(S) activates chaperone genes
reactome	R-HSA-381070	IRE1alpha activates chaperones
reactome	R-HSA-381119	Unfolded Protein Response (UPR)
reactome	R-HSA-392499	Metabolism of proteins

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLHDC3

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