KLHDC3


Summary: The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kelch domain containing 3MIM:611248Ensembl:ENSG00000124702HGNC:HGNC:20704PA1348927826p21.1

GO terms in KLHDC3


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0007131reciprocal meiotic recombination
BPTASGO:0036498IRE1-mediated unfolded protein response
CCIBAGO:0000790nuclear chromatin
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
MFIBAGO:0003682chromatin binding
MFIDAGO:0003682chromatin binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: KLHDC3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLHDC3


DatabasePathway IDPathway Des.
wikipathwaysWP3472XBP1(S) activates chaperone genes
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLHDC3

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