KLK6
Summary: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kallikrein related peptidase 6 | MIM:602652 | Ensembl:ENSG00000167755 | HGNC:HGNC:6367 | PA30156 | 19q13.41 |
GO terms in KLK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0007417 | central nervous system development |
| BP | NAS | GO:0009611 | response to wounding |
| BP | IEA | GO:0010975 | regulation of neuron projection development |
| BP | NAS | GO:0016540 | protein autoprocessing |
| BP | NAS | GO:0030574 | collagen catabolic process |
| BP | NAS | GO:0042246 | tissue regeneration |
| BP | NAS | GO:0042445 | hormone metabolic process |
| BP | NAS | GO:0042552 | myelination |
| BP | NAS | GO:0042982 | amyloid precursor protein metabolic process |
| BP | NAS | GO:0045595 | regulation of cell differentiation |
| BP | IDA | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway |
| BP | IMP | GO:0070997 | neuron death |
| CC | IDA | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0030141 | secretory granule |
| MF | IDA | GO:0004252 | serine-type endopeptidase activity |
| MF | NAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: KLK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLK6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLK6
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.