KMT2E


Summary: This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lysine methyltransferase 2EMIM:608444Ensembl:ENSG00000005483HGNC:HGNC:18541PA385687q22.3

GO terms in KMT2E


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0018024histone-lysine N-methyltransferase activity
MFTASGO:0018024histone-lysine N-methyltransferase activity
MFIPIGO:0019899enzyme binding
MFIDAGO:0035064methylated histone binding
MFIMPGO:0035064methylated histone binding
MFIEAGO:0046872metal ion binding
CCIDAGO:0000785chromatin
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIEAGO:0005815microtubule organizing center
CCIEAGO:0005886plasma membrane
CCIEAGO:0016607nuclear speck
CCIDAGO:0032991protein-containing complex
CCIDAGO:0035327transcriptionally active chromatin
BPISSGO:0002446neutrophil mediated immunity
BPISSGO:0006306DNA methylation
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0007050cell cycle arrest
BPISSGO:0030218erythrocyte differentiation
BPIEAGO:0034968histone lysine methylation
BPISSGO:0042119neutrophil activation
BPTASGO:0045652regulation of megakaryocyte differentiation
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:1900087positive regulation of G1/S transition of mitotic cell cycle
BPIMPGO:1905437positive regulation of histone H3-K4 trimethylation

Gene expression in normal tissue: KMT2E

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KMT2E


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
kegghsa00310Lysine degradation - Homo sapiens (human)
wikipathwaysWP2369Histone Modifications

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KMT2E

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