KRT13


Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
keratin 13MIM:148065Ensembl:ENSG00000171401HGNC:HGNC:6415PA3020217q21.2

GO terms in KRT13


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0007010cytoskeleton organization
BPIEAGO:0009314response to radiation
BPTASGO:0031424keratinization
BPIEAGO:0043587tongue morphogenesis
BPTASGO:0070268cornification
BPIEAGO:0071300cellular response to retinoic acid
CCHDAGO:0005634nucleus
CCTASGO:0005829cytosol
CCIDAGO:0045095keratin filament
CCIDAGO:0045111intermediate filament cytoskeleton
CCHDAGO:0070062extracellular exosome
MFIEAGO:0005198structural molecule activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: KRT13

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KRT13


DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-6805567Keratinization
reactomeR-HSA-6809371Formation of the cornified envelope

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KRT13

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