KRT18
Summary: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| keratin 18 | MIM:148070 | Ensembl:ENSG00000111057 | HGNC:HGNC:6430 | PA30217 | 12q13.13 |
Gene Categories:
DRUGGABLE GENOMEGO terms in KRT18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0097110 | scaffold protein binding |
| MF | HDA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005882 | intermediate filament |
| CC | HDA | GO:0005913 | cell-cell adherens junction |
| CC | IDA | GO:0034451 | centriolar satellite |
| CC | IDA | GO:0045095 | keratin filament |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0071944 | cell periphery |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0031424 | keratinization |
| BP | IEA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:0043000 | Golgi to plasma membrane CFTR protein transport |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0045104 | intermediate filament cytoskeleton organization |
| BP | TAS | GO:0070268 | cornification |
| BP | IEA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IEA | GO:0097284 | hepatocyte apoptotic process |
| BP | IEA | GO:0098609 | cell-cell adhesion |
Gene expression in normal tissue: KRT18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KRT18
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-6805567 | Keratinization |
| reactome | R-HSA-6809371 | Formation of the cornified envelope |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KRT18
CLASSFICATION
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