KYNU
Summary: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kynureninase | MIM:605197 | Ensembl:ENSG00000115919 | HGNC:HGNC:6469 | PA30258 | 2q22.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in KYNU
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0006569 | tryptophan catabolic process |
| BP | TAS | GO:0006569 | tryptophan catabolic process |
| BP | IEA | GO:0009435 | NAD biosynthetic process |
| BP | IMP | GO:0009435 | NAD biosynthetic process |
| BP | IBA | GO:0019441 | tryptophan catabolic process to kynurenine |
| BP | IEA | GO:0019442 | tryptophan catabolic process to acetyl-CoA |
| BP | IDA | GO:0019805 | quinolinate biosynthetic process |
| BP | IDA | GO:0034341 | response to interferon-gamma |
| BP | IMP | GO:0034516 | response to vitamin B6 |
| BP | IBA | GO:0043420 | anthranilate metabolic process |
| BP | IDA | GO:0043420 | anthranilate metabolic process |
| BP | IEA | GO:0097053 | L-kynurenine catabolic process |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IEA | GO:0030170 | pyridoxal phosphate binding |
| MF | IBA | GO:0030429 | kynureninase activity |
| MF | IDA | GO:0030429 | kynureninase activity |
| MF | IMP | GO:0030429 | kynureninase activity |
| MF | TAS | GO:0030429 | kynureninase activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0061981 | 3-hydroxykynureninase activity |
Gene expression in normal tissue: KYNU
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KYNU
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00063 | Tryptophan Metabolism |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP2485 | NAD Biosynthesis II (from tryptophan) |
| wikipathways | WP465 | Tryptophan metabolism |
| humancyc | NADSYN-PWY | NAD de novo biosynthesis |
| humancyc | PWY-5651 | tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde |
| humancyc | PWY-6309 | L-kynurenine degradation |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| humancyc | TRYPTOPHAN-DEGRADATION-1 | tryptophan degradation |
| kegg | hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-6788656 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism |
| reactome | R-HSA-71240 | Tryptophan catabolism |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KYNU
CLASSFICATION
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