Summary: This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014].

galectin 3MIM:153619Ensembl:ENSG00000131981HGNC:HGNC:6563PA3034014q22.3

Gene Categories:


GO terms in LGALS3

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0001772immunological synapse
CCHDAGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIEAGO:0005681spliceosomal complex
CCIDAGO:0005743mitochondrial inner membrane
CCTASGO:0005886plasma membrane
CCTASGO:0030667secretory granule membrane
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome
CCTASGO:0101003ficolin-1-rich granule membrane
BPIDAGO:0002548monocyte chemotaxis
BPIEAGO:0006397mRNA processing
BPIEAGO:0008380RNA splicing
BPIDAGO:0030593neutrophil chemotaxis
BPIEPGO:0030855epithelial cell differentiation
BPIMPGO:0042129regulation of T cell proliferation
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0045087innate immune response
BPTASGO:0045637regulation of myeloid cell differentiation
BPIDAGO:0045806negative regulation of endocytosis
BPIDAGO:0048245eosinophil chemotaxis
BPIDAGO:0048246macrophage chemotaxis
BPISSGO:0050860negative regulation of T cell receptor signaling pathway
BPIDAGO:0050918positive chemotaxis
BPIDAGO:0070232regulation of T cell apoptotic process
BPIDAGO:0071674mononuclear cell migration
BPIDAGO:0071677positive regulation of mononuclear cell migration
BPIDAGO:0090280positive regulation of calcium ion import
BPIMPGO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPISSGO:2000521negative regulation of immunological synapse formation
BPISSGO:2001189negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
BPIDAGO:2001200positive regulation of dendritic cell differentiation
BPIDAGO:2001237negative regulation of extrinsic apoptotic signaling pathway
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIDAGO:0019863IgE binding
MFIEAGO:0030246carbohydrate binding
MFIDAGO:0042056chemoattractant activity
MFIDAGO:0043236laminin binding

Gene expression in normal tissue: LGALS3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LGALS3

DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-879415Advanced glycosylation endproduct receptor signaling
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
reactomeR-HSA-8941333RUNX2 regulates genes involved in differentiation of myeloid cells
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
pidras_pathwayRegulation of Ras family activation
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP4105Transcriptional regulation by RUNX1

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LGALS3