Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].

galectin 9MIM:601879Ensembl:ENSG00000168961HGNC:HGNC:6570PA3034717q11.2

Gene Categories:


GO terms in LGALS9

Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0002519natural killer cell tolerance induction
BPIDAGO:0006954inflammatory response
BPIDAGO:0007565female pregnancy
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0010629negative regulation of gene expression
BPIMPGO:0010629negative regulation of gene expression
BPIMPGO:0032496response to lipopolysaccharide
BPIDAGO:0032673regulation of interleukin-4 production
BPIDAGO:0032674regulation of interleukin-5 production
BPIMPGO:0032682negative regulation of chemokine production
BPIDAGO:0032689negative regulation of interferon-gamma production
BPIMPGO:0032720negative regulation of tumor necrosis factor production
BPIDAGO:0032753positive regulation of interleukin-4 production
BPIMPGO:0032753positive regulation of interleukin-4 production
BPIDAGO:0032834positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
BPIDAGO:0034134toll-like receptor 2 signaling pathway
BPIDAGO:0034142toll-like receptor 4 signaling pathway
BPIDAGO:0038066p38MAPK cascade
BPHMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0043305negative regulation of mast cell degranulation
BPIDAGO:0045953negative regulation of natural killer cell mediated cytotoxicity
BPIMPGO:0046007negative regulation of activated T cell proliferation
BPIDAGO:0046598positive regulation of viral entry into host cell
BPIDAGO:0050718positive regulation of interleukin-1 beta secretion
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0060135maternal process involved in female pregnancy
BPIDAGO:0070241positive regulation of activated T cell autonomous cell death
BPIDAGO:0070371ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070555response to interleukin-1
BPIDAGO:0071346cellular response to interferon-gamma
BPIDAGO:0071636positive regulation of transforming growth factor beta production
BPIMPGO:0071639positive regulation of monocyte chemotactic protein-1 production
BPIMPGO:0097029mature conventional dendritic cell differentiation
BPIMPGO:0098586cellular response to virus
BPIMPGO:1900744regulation of p38MAPK cascade
BPIMPGO:1901224positive regulation of NIK/NF-kappaB signaling
BPIDAGO:1902715positive regulation of interferon-gamma secretion
BPIDAGO:1904469positive regulation of tumor necrosis factor secretion
BPIMPGO:2000484positive regulation of interleukin-8 secretion
BPIMPGO:2000510positive regulation of dendritic cell chemotaxis
BPIDAGO:2000562negative regulation of CD4-positive, alpha-beta T cell proliferation
BPIDAGO:2000563positive regulation of CD4-positive, alpha-beta T cell proliferation
BPIDAGO:2000667positive regulation of interleukin-13 secretion
BPIDAGO:2000670positive regulation of dendritic cell apoptotic process
BPIMPGO:2000778positive regulation of interleukin-6 secretion
BPIDAGO:2001181positive regulation of interleukin-10 secretion
BPIMPGO:2001184positive regulation of interleukin-12 secretion
BPIDAGO:2001190positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
BPIMPGO:2001200positive regulation of dendritic cell differentiation
BPIMPGO:2001269positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
CCIDAGO:0005615extracellular space
MFTASGO:0005534galactose binding
MFIPIGO:0019899enzyme binding
MFIDAGO:0030246carbohydrate binding
MFIMPGO:0048030disaccharide binding

Gene expression in normal tissue: LGALS9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LGALS9

DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway
pharmgkbPA166114721Uricosurics Pathway, Pharmacodynamics
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LGALS9