LGALS9
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| galectin 9 | MIM:601879 | Ensembl:ENSG00000168961 | HGNC:HGNC:6570 | PA30347 | 17q11.2 |
GO terms in LGALS9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0002519 | natural killer cell tolerance induction |
| BP | IEA | GO:0006935 | chemotaxis |
| BP | IDA | GO:0006954 | inflammatory response |
| BP | IDA | GO:0007565 | female pregnancy |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0032496 | response to lipopolysaccharide |
| BP | IDA | GO:0032673 | regulation of interleukin-4 production |
| BP | IDA | GO:0032674 | regulation of interleukin-5 production |
| BP | IMP | GO:0032682 | negative regulation of chemokine production |
| BP | IDA | GO:0032689 | negative regulation of interferon-gamma production |
| BP | IMP | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IDA | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IMP | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IDA | GO:0032834 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response |
| BP | IDA | GO:0034134 | toll-like receptor 2 signaling pathway |
| BP | IDA | GO:0034142 | toll-like receptor 4 signaling pathway |
| BP | IDA | GO:0038066 | p38MAPK cascade |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043305 | negative regulation of mast cell degranulation |
| BP | IDA | GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity |
| BP | IMP | GO:0046007 | negative regulation of activated T cell proliferation |
| BP | IDA | GO:0046598 | positive regulation of viral entry into host cell |
| BP | IDA | GO:0050718 | positive regulation of interleukin-1 beta secretion |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0060135 | maternal process involved in female pregnancy |
| BP | IDA | GO:0070241 | positive regulation of activated T cell autonomous cell death |
| BP | IDA | GO:0070371 | ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070555 | response to interleukin-1 |
| BP | IDA | GO:0071346 | cellular response to interferon-gamma |
| BP | IDA | GO:0071636 | positive regulation of transforming growth factor beta production |
| BP | IMP | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production |
| BP | IMP | GO:0097029 | mature conventional dendritic cell differentiation |
| BP | IMP | GO:0098586 | cellular response to virus |
| BP | IMP | GO:1900744 | regulation of p38MAPK cascade |
| BP | IMP | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IDA | GO:1902715 | positive regulation of interferon-gamma secretion |
| BP | IDA | GO:1904469 | positive regulation of tumor necrosis factor secretion |
| BP | IMP | GO:2000484 | positive regulation of interleukin-8 secretion |
| BP | IMP | GO:2000510 | positive regulation of dendritic cell chemotaxis |
| BP | IDA | GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation |
| BP | IDA | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation |
| BP | IDA | GO:2000667 | positive regulation of interleukin-13 secretion |
| BP | IDA | GO:2000670 | positive regulation of dendritic cell apoptotic process |
| BP | IMP | GO:2000778 | positive regulation of interleukin-6 secretion |
| BP | IDA | GO:2001181 | positive regulation of interleukin-10 secretion |
| BP | IMP | GO:2001184 | positive regulation of interleukin-12 secretion |
| BP | IDA | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| BP | IMP | GO:2001200 | positive regulation of dendritic cell differentiation |
| BP | IMP | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| MF | TAS | GO:0005534 | galactose binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IDA | GO:0030246 | carbohydrate binding |
| MF | IMP | GO:0048030 | disaccharide binding |
Gene expression in normal tissue: LGALS9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LGALS9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| pharmgkb | PA166114721 | Uricosurics Pathway, Pharmacodynamics |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LGALS9
CLASSFICATION
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