LHX9


Summary: This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
LIM homeobox 9MIM:606066Ensembl:ENSG00000143355HGNC:HGNC:14222PA303681q31.3

GO terms in LHX9


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISSGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIEAGO:0043565sequence-specific DNA binding
MFIEAGO:0046872metal ion binding
CCIEAGO:0005634nucleus
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0008283cell proliferation
BPIEAGO:0008584male gonad development
BPIEAGO:0008585female gonad development
BPIEAGO:0035262gonad morphogenesis
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0097380dorsal spinal cord interneuron anterior axon guidance

Gene expression in normal tissue: LHX9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LHX9


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LHX9

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