LRPAP1


Summary: This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
LDL receptor related protein associated protein 1MIM:104225Ensembl:ENSG00000163956HGNC:HGNC:6701PA304584p16.3

GO terms in LRPAP1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0001540amyloid-beta binding
MFTASGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008201heparin binding
MFIEAGO:0035473lipase binding
MFIDAGO:0048019receptor antagonist activity
MFTASGO:0048019receptor antagonist activity
MFIDAGO:0050750low-density lipoprotein particle receptor binding
MFTASGO:0050750low-density lipoprotein particle receptor binding
MFIPIGO:0070326very-low-density lipoprotein particle receptor binding
CCTASGO:0005576extracellular region
CCIDAGO:0005768endosome
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005793endoplasmic reticulum-Golgi intermediate compartment
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0005796Golgi lumen
CCIDAGO:0005801cis-Golgi network
CCIDAGO:0005886plasma membrane
CCIEAGO:0009986cell surface
CCIEAGO:0031904endosome lumen
CCIDAGO:0048237rough endoplasmic reticulum lumen
BPIGIGO:0002091negative regulation of receptor internalization
BPIDAGO:0010916negative regulation of very-low-density lipoprotein particle clearance
BPIDAGO:0032091negative regulation of protein binding
BPIMPGO:0045056transcytosis
BPIDAGO:0048259regulation of receptor-mediated endocytosis
BPIGIGO:0060548negative regulation of cell death
BPTASGO:1900116extracellular negative regulation of signal transduction
BPIGIGO:1900222negative regulation of amyloid-beta clearance
BPTASGO:1900223positive regulation of amyloid-beta clearance

Gene expression in normal tissue: LRPAP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LRPAP1


DatabasePathway IDPathway Des.
biocartaintegrinpathwayintegrin signaling pathway
kegghsa04979Cholesterol metabolism - Homo sapiens (human)
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
pidlis1pathwayLissencephaly gene (LIS1) in neuronal migration and development
pidreelinpathwayReelin signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRPAP1

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