LYZ
Summary: This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysozyme | MIM:153450 | Ensembl:ENSG00000090382 | HGNC:HGNC:6740 | PA30503 | 12q15 |
Gene Categories:
DRUGGABLE GENOMEGO terms in LYZ
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003796 | lysozyme activity |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005615 | extracellular space |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| BP | HEP | GO:0001895 | retina homeostasis |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0019730 | antimicrobial humoral response |
| BP | IEA | GO:0019835 | cytolysis |
| BP | IDA | GO:0031640 | killing of cells of other organism |
| BP | IDA | GO:0042742 | defense response to bacterium |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IBA | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IBA | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IDA | GO:0050830 | defense response to Gram-positive bacterium |
Gene expression in normal tissue: LYZ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LYZ
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6803157 | Antimicrobial peptides |
| reactome | R-HSA-977225 | Amyloid fiber formation |
| pid | cmyb_pathway | C-MYB transcription factor network |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| wikipathways | WP3936 | Macrophage markers |
| wikipathways | WP4146 | Macrophage markers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LYZ
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