LYZ


Summary: This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lysozymeMIM:153450Ensembl:ENSG00000090382HGNC:HGNC:6740PA3050312q15

Gene Categories:

DRUGGABLE GENOME

GO terms in LYZ


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003796lysozyme activity
MFIPIGO:0042802identical protein binding
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0005615extracellular space
CCTASGO:0035578azurophil granule lumen
CCTASGO:0035580specific granule lumen
CCHDAGO:0070062extracellular exosome
CCTASGO:1904724tertiary granule lumen
BPHEPGO:0001895retina homeostasis
BPTASGO:0006954inflammatory response
BPTASGO:0019730antimicrobial humoral response
BPIEAGO:0019835cytolysis
BPIDAGO:0031640killing of cells of other organism
BPIDAGO:0042742defense response to bacterium
BPTASGO:0043312neutrophil degranulation
BPTASGO:0044267cellular protein metabolic process
BPIBAGO:0050829defense response to Gram-negative bacterium
BPIBAGO:0050830defense response to Gram-positive bacterium
BPIDAGO:0050830defense response to Gram-positive bacterium

Gene expression in normal tissue: LYZ

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LYZ


DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6803157Antimicrobial peptides
reactomeR-HSA-977225Amyloid fiber formation
pidcmyb_pathwayC-MYB transcription factor network
kegghsa04970Salivary secretion - Homo sapiens (human)
wikipathwaysWP3936Macrophage markers
wikipathwaysWP4146Macrophage markers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LYZ

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