MAGED2


Summary: This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MAGE family member D2MIM:300470Ensembl:ENSG00000102316HGNC:HGNC:16353PA30560Xp11.21

GO terms in MAGED2


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCTASGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCHDAGO:0016020membrane
CCTASGO:0031093platelet alpha granule lumen
BPTASGO:0002576platelet degranulation
BPIMPGO:0007565female pregnancy
BPIMPGO:0070294renal sodium ion absorption

Gene expression in normal tissue: MAGED2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAGED2


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAGED2

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