Summary: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008].

membrane associated guanylate kinase, WW and PDZ domain containing 2MIM:606382Ensembl:ENSG00000187391HGNC:HGNC:18957PA1426714847q21.11

GO terms in MAGI2

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0002092positive regulation of receptor internalization
BPNASGO:0003402planar cell polarity pathway involved in axis elongation
BPISSGO:0008285negative regulation of cell proliferation
BPISSGO:0010976positive regulation of neuron projection development
BPISSGO:0030336negative regulation of cell migration
BPIDAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPISSGO:0032926negative regulation of activin receptor signaling pathway
BPISSGO:0038180nerve growth factor signaling pathway
BPISSGO:0043113receptor clustering
BPISSGO:0051291protein heterooligomerization
BPIDAGO:0051898negative regulation of protein kinase B signaling
BPISSGO:0060395SMAD protein signal transduction
BPISSGO:0071850mitotic cell cycle arrest
BPISSGO:0072015glomerular visceral epithelial cell development
BPIEAGO:0097118neuroligin clustering involved in postsynaptic membrane assembly
BPISSGO:1990090cellular response to nerve growth factor stimulus
BPIEAGO:2000809positive regulation of synaptic vesicle clustering
CCISSGO:0005770late endosome
CCIDAGO:0005886plasma membrane
CCIDAGO:0005923bicellular tight junction
CCISSGO:0014069postsynaptic density
CCISSGO:0032991protein-containing complex
CCISSGO:0036057slit diaphragm
CCISSGO:0048471perinuclear region of cytoplasm
MFIPIGO:0005515protein binding
MFIPIGO:0019902phosphatase binding
MFIDAGO:0030159receptor signaling complex scaffold activity
MFIPIGO:0031697beta-1 adrenergic receptor binding
MFISSGO:0046332SMAD binding
MFISSGO:0070699type II activin receptor binding

Gene expression in normal tissue: MAGI2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAGI2

DatabasePathway IDPathway Des.
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-373753Nephrin family interactions

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAGI2