MAGOH


Summary: Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mago homolog, exon junction complex subunitMIM:602603Ensembl:ENSG00000162385HGNC:HGNC:6815PA305631p32.3

GO terms in MAGOH


Term TypeEvidence TypeGO Term IDGO Des.
BPIGIGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPIMPGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPIMPGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPICGO:0000398mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006405RNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPIEAGO:0006417regulation of translation
BPIBAGO:0008380RNA splicing
BPTASGO:0031124mRNA 3'-end processing
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIEAGO:0016607nuclear speck
CCIBAGO:0035145exon-exon junction complex
CCIDAGO:0035145exon-exon junction complex
CCIBAGO:0071013catalytic step 2 spliceosome
CCIDAGO:0071013catalytic step 2 spliceosome
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: MAGOH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAGOH


DatabasePathway IDPathway Des.
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa03015mRNA surveillance pathway - Homo sapiens (human)
kegghsa03040Spliceosome - Homo sapiens (human)
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72187mRNA 3'-end processing
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAGOH

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