MAPK14


Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase 14MIM:600289Ensembl:ENSG00000112062HGNC:HGNC:6876PA306216p21.31

GO terms in MAPK14


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004707MAP kinase activity
MFIDAGO:0004707MAP kinase activity
MFTASGO:0004708MAP kinase kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019903protein phosphatase binding
MFIPIGO:0048273mitogen-activated protein kinase p38 binding
MFISSGO:0051525NFAT protein binding
CCIEAGO:0000922spindle pole
CCTASGO:0005576extracellular region
CCIBAGO:0005634nucleus
CCISSGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCTASGO:0005829cytosol
CCIDAGO:0016607nuclear speck
CCTASGO:0034774secretory granule lumen
CCTASGO:1904813ficolin-1-rich granule lumen
BPIEAGO:0000077DNA damage checkpoint
BPTASGO:0000187activation of MAPK activity
BPIEAGO:0000902cell morphogenesis
BPIEAGO:0001502cartilage condensation
BPIEAGO:0001525angiogenesis
BPIEAGO:0001890placenta development
BPIEAGO:0002062chondrocyte differentiation
BPIEAGO:0002741positive regulation of cytokine secretion involved in immune response
BPIEAGO:0006006glucose metabolic process
BPIEAGO:0006351transcription, DNA-templated
BPISSGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006915apoptotic process
BPTASGO:0006935chemotaxis
BPTASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPIEAGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway
BPIEAGO:0007519skeletal muscle tissue development
BPIBAGO:0010468regulation of gene expression
BPIMPGO:0010628positive regulation of gene expression
BPIEAGO:0010759positive regulation of macrophage chemotaxis
BPISSGO:0010831positive regulation of myotube differentiation
BPIEAGO:0014835myoblast differentiation involved in skeletal muscle regeneration
BPISSGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0019395fatty acid oxidation
BPIEAGO:0030278regulation of ossification
BPISSGO:0030316osteoclast differentiation
BPIMPGO:0031281positive regulation of cyclase activity
BPIEAGO:0031663lipopolysaccharide-mediated signaling pathway
BPIEAGO:0032495response to muramyl dipeptide
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIEAGO:0035994response to muscle stretch
BPISSGO:0038066p38MAPK cascade
BPIEAGO:0042307positive regulation of protein import into nucleus
BPIMPGO:0042770signal transduction in response to DNA damage
BPTASGO:0043312neutrophil degranulation
BPIMPGO:0043536positive regulation of blood vessel endothelial cell migration
BPIMPGO:0045648positive regulation of erythrocyte differentiation
BPISSGO:0045663positive regulation of myoblast differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046326positive regulation of glucose import
BPIMPGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEAGO:0051146striated muscle cell differentiation
BPTASGO:0051149positive regulation of muscle cell differentiation
BPIEAGO:0060045positive regulation of cardiac muscle cell proliferation
BPTASGO:00709353'-UTR-mediated mRNA stabilization
BPIDAGO:0071222cellular response to lipopolysaccharide
BPIMPGO:0071223cellular response to lipoteichoic acid
BPIBAGO:0071310cellular response to organic substance
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0071479cellular response to ionizing radiation
BPIEAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIEAGO:0090336positive regulation of brown fat cell differentiation
BPIMPGO:0090400stress-induced premature senescence
BPIMPGO:0098586cellular response to virus
BPIDAGO:1900015regulation of cytokine production involved in inflammatory response
BPISSGO:1901741positive regulation of myoblast fusion
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIEAGO:1905050positive regulation of metallopeptidase activity
BPIMPGO:2000379positive regulation of reactive oxygen species metabolic process
BPIMPGO:2001184positive regulation of interleukin-12 secretion

Gene expression in normal tissue: MAPK14

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPK14


DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP1539Angiogenesis
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2035Follicle Stimulating Hormone (FSH) signaling pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3668Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3874Canonical and Non-Canonical TGF-B signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP408Oxidative Stress
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP727Monoamine Transport
wikipathwaysWP75Toll-like Receptor Signaling Pathway
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidar_tf_pathwayRegulation of Androgen receptor activity
pidatf2_pathwayATF-2 transcription factor network
pidbcr_5pathwayBCR signaling pathway
pidcd40_pathwayCD40/CD40L signaling
pidcdc42_pathwayCDC42 signaling events
pidcxcr3pathwayCXCR3-mediated signaling events
pidendothelinpathwayEndothelins
pidepopathwayEPO signaling pathway
pidfaspathwayFAS (CD95) signaling pathway
pidfgf_pathwayFGF signaling pathway
pidil12_2pathwayIL12-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidlymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
pidp53regulationpathwayp53 pathway
pidp73pathwayp73 transcription factor network
pidrac1_pathwayRAC1 signaling pathway
pidrapid_gr_pathwayRapid glucocorticoid signaling
pidrb_1pathwayRegulation of retinoblastoma protein
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pids1p_s1p2_pathwayS1P2 pathway
pidtxa2pathwayThromboxane A2 receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
biocarta41bbpathwaythe 41bb-dependent immune response
biocartabcrpathwaybcr signaling pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartadsppathwayregulation of map kinase pathways through dual specificity phosphatases
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartahdacpathwaycontrol of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
biocartail10pathwayil-10 anti-inflammatory signaling pathway
biocartail12pathwayil12 and stat4 dependent signaling pathway in th1 development
biocartail1rpathwaysignal transduction through il1r
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamapkpathwaymapkinase signaling pathway
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartap38mapkpathwayp38 mapk signaling pathway
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartasmrtepathwaymap kinase inactivation of smrt corepressor
biocartastresspathwaytnf/stress related signaling
biocartatollpathwaytoll-like receptor pathway
biocartatsp1pathwaytsp-1 induced apoptosis in microvascular endothelial cell
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylation
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-376172DSCAM interactions
reactomeR-HSA-392518Signal amplification
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418592ADP signalling through P2Y purinoceptor 1
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-432142Platelet sensitization by LDL
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450302activated TAK1 mediates p38 MAPK activation
reactomeR-HSA-450341Activation of the AP-1 family of transcription factors
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-450604KSRP (KHSRP) binds and destabilizes mRNA
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_BCRBCR
netpathPathway_CRHCRH
netpathPathway_EGFR1EGFR1
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
netpathPathway_GastrinGastrin
netpathPathway_IL1IL1
netpathPathway_IL2IL2
netpathPathway_IL4IL4
netpathPathway_IL5IL5
netpathPathway_IL6IL6
netpathPathway_KitReceptorKitReceptor
netpathPathway_LeptinLeptin
netpathPathway_ProlactinProlactin
netpathPathway_RAGERAGE
netpathPathway_RANKLRANKL
netpathPathway_TCRTCR
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_TNFalphaTNFalpha
netpathPathway_TSLPTSLP

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD484Pluripotin6
iGMDRD705Nakiterpiosin6
iGMDRD329Merck603
iGMDRD398Sepantronium6
iGMDRD414MST-3129
iGMDRD126Tipifarnib6
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK14

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