Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

minichromosome maintenance complex component 7MIM:600592Ensembl:ENSG00000166508HGNC:HGNC:6950PA306977q22.1

Gene Categories:


GO terms in MCM7

Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0042555MCM complex
CCIMPGO:0042555MCM complex
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0006260DNA replication
BPIEAGO:0006268DNA unwinding involved in DNA replication
BPIEAGO:0006270DNA replication initiation
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0008283cell proliferation
BPIMPGO:0042325regulation of phosphorylation
BPIEAGO:0042493response to drug
BPIEAGO:0071364cellular response to epidermal growth factor stimulus
BPIEAGO:0071466cellular response to xenobiotic stimulus
MFTASGO:0003677DNA binding
MFIEAGO:0003697single-stranded DNA binding
MFIDAGO:0004003ATP-dependent DNA helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: MCM7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MCM7

DatabasePathway IDPathway Des.
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP179Cell Cycle
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP466DNA Replication
pidatr_pathwayATR signaling pathway
kegghsa03030DNA replication - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
biocartamcmpathwaycdk regulation of dna replication
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-176187Activation of ATR in response to replication stress
reactomeR-HSA-176974Unwinding of DNA
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-68867Assembly of the pre-replicative complex
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68949Orc1 removal from chromatin
reactomeR-HSA-68962Activation of the pre-replicative complex
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69190DNA strand elongation
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MCM7