MCM9
Summary: The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| minichromosome maintenance 9 homologous recombination repair factor | MIM:610098 | Ensembl:ENSG00000111877 | HGNC:HGNC:21484 | PA162395071 | 6q22.31 |
Gene Categories:
DNA REPAIRGO terms in MCM9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0097362 | MCM8-MCM9 complex |
| BP | IDA | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IEA | GO:0006270 | DNA replication initiation |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | ISS | GO:0007292 | female gamete generation |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0004386 | helicase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: MCM9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCM9
CLASSFICATION
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