MED17


Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mediator complex subunit 17MIM:603810Ensembl:ENSG00000042429HGNC:HGNC:2375PA16239544311q21

GO terms in MED17


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003712transcription coregulator activity
MFIDAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFNASGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0038023signaling receptor activity
MFNASGO:0042809vitamin D receptor binding
MFIDAGO:0046966thyroid hormone receptor binding
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIDAGO:0006357regulation of transcription by RNA polymerase II
BPIDAGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIDAGO:0030518intracellular steroid hormone receptor signaling pathway
BPIDAGO:0030521androgen receptor signaling pathway
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005667transcription factor complex
CCHDAGO:0016020membrane
CCIBAGO:0016592mediator complex
CCIDAGO:0016592mediator complex
CCIBAGO:0070847core mediator complex

Gene expression in normal tissue: MED17

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MED17


DatabasePathway IDPathway Des.
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD935JQ121
iGMDRD179Shikonin1
iGMDRD662JQ-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MED17

​​​​