METAP2


Summary: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
methionyl aminopeptidase 2MIM:601870Ensembl:ENSG00000111142HGNC:HGNC:16672PA3076512q22

GO terms in METAP2


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIDAGO:0004177aminopeptidase activity
MFTASGO:0004177aminopeptidase activity
MFIDAGO:0008235metalloexopeptidase activity
MFIEAGO:0046872metal ion binding
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
BPIDAGO:0016485protein processing
BPIDAGO:0018206peptidyl-methionine modification
BPTASGO:0022400regulation of rhodopsin mediated signaling pathway
BPIDAGO:0031365N-terminal protein amino acid modification

Gene expression in normal tissue: METAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in METAP2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in METAP2

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