MFAP5
Summary: This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microfibril associated protein 5 | MIM:601103 | Ensembl:ENSG00000197614 | HGNC:HGNC:29673 | PA134915148 | 12p13.31 |
Gene Categories:
DRUGGABLE GENOMEGO terms in MFAP5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005201 | extracellular matrix structural constituent |
| CC | ISS | GO:0001527 | microfibril |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | ISS | GO:0060216 | definitive hemopoiesis |
| BP | IEA | GO:0097435 | supramolecular fiber organization |
Gene expression in normal tissue: MFAP5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MFAP5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | notch_pathway | Notch signaling pathway |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
| reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MFAP5
CLASSFICATION
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