MFAP5
Summary: This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
microfibril associated protein 5 | MIM:601103 | Ensembl:ENSG00000197614 | HGNC:HGNC:29673 | PA134915148 | 12p13.31 |
Gene Categories:
DRUGGABLE GENOMEGO terms in MFAP5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0005201 | extracellular matrix structural constituent |
CC | ISS | GO:0001527 | microfibril |
CC | TAS | GO:0005576 | extracellular region |
CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
BP | TAS | GO:0030198 | extracellular matrix organization |
BP | ISS | GO:0060216 | definitive hemopoiesis |
BP | IEA | GO:0097435 | supramolecular fiber organization |
Gene expression in normal tissue: MFAP5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MFAP5
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | notch_pathway | Notch signaling pathway |
wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
reactome | R-HSA-1474244 | Extracellular matrix organization |
reactome | R-HSA-1474244 | Extracellular matrix organization |
reactome | R-HSA-1566948 | Elastic fibre formation |
reactome | R-HSA-1566948 | Elastic fibre formation |
reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MFAP5