MGAT4B


Summary: This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase BMIM:604561Ensembl:ENSG00000161013HGNC:HGNC:7048PA307835q35.3

GO terms in MGAT4B


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0008454alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
MFIEAGO:0046872metal ion binding
BPIEAGO:0006487protein N-linked glycosylation
BPTASGO:0006491N-glycan processing
CCTASGO:0000139Golgi membrane
CCIEAGO:0016021integral component of membrane

Gene expression in normal tissue: MGAT4B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MGAT4B


DatabasePathway IDPathway Des.
kegghsa00510N-Glycan biosynthesis - Homo sapiens (human)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
reactomeR-HSA-975576N-glycan antennae elongation in the medial/trans-Golgi
reactomeR-HSA-975577N-Glycan antennae elongation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MGAT4B

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