MGMT
Summary: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| O-6-methylguanine-DNA methyltransferase | MIM:156569 | Ensembl:ENSG00000170430 | HGNC:HGNC:7059 | PA239 | 10q26.3 |
GO terms in MGMT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006266 | DNA ligation |
| BP | IEA | GO:0006306 | DNA methylation |
| BP | TAS | GO:0006307 | DNA dealkylation involved in DNA repair |
| BP | IEA | GO:0034599 | cellular response to oxidative stress |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0051593 | response to folic acid |
| BP | IEA | GO:0060644 | mammary gland epithelial cell differentiation |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IEA | GO:0071479 | cellular response to ionizing radiation |
| BP | IDA | GO:2000781 | positive regulation of double-strand break repair |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0016020 | membrane |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003908 | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | TAS | GO:0008168 | methyltransferase activity |
| MF | TAS | GO:0009008 | DNA-methyltransferase activity |
Gene expression in normal tissue: MGMT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MGMT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| pharmgkb | PA2035 | Cyclophosphamide Pathway, Pharmacodynamics |
| reactome | R-HSA-5657655 | MGMT-mediated DNA damage reversal |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73942 | DNA Damage Reversal |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD44 | Temozolomide | 3 |
| iGMDRD485 | O(6)-benzylguanine | 1 |
| iGMDRD13 | Carmustine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MGMT
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