MGST1


Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
microsomal glutathione S-transferase 1MIM:138330Ensembl:ENSG00000008394HGNC:HGNC:7061PA3079112p12.3

GO terms in MGST1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004364glutathione transferase activity
MFIDAGO:0004364glutathione transferase activity
MFTASGO:0004364glutathione transferase activity
MFIDAGO:0004602glutathione peroxidase activity
MFIPIGO:0005515protein binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0043295glutathione binding
MFIBAGO:0050220prostaglandin-E synthase activity
MFIBAGO:0050220prostaglandin-E synthase activity
BPIBAGO:0001516prostaglandin biosynthetic process
BPIBAGO:0001516prostaglandin biosynthetic process
BPIBAGO:0006749glutathione metabolic process
BPTASGO:0006805xenobiotic metabolic process
BPIEAGO:0010243response to organonitrogen compound
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0033327Leydig cell differentiation
BPIEAGO:0042493response to drug
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0055114oxidation-reduction process
BPIDAGO:0055114oxidation-reduction process
BPISSGO:0070207protein homotrimerization
BPIDAGO:0071449cellular response to lipid hydroperoxide
BPIEAGO:0098869cellular oxidant detoxification
BPTASGO:1901687glutathione derivative biosynthetic process
CCIEAGO:0005634nucleus
CCIBAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCIEAGO:0005741mitochondrial outer membrane
CCISSGO:0005778peroxisomal membrane
CCISSGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0005886plasma membrane
CCISSGO:0016021integral component of membrane
CCTASGO:0035577azurophil granule membrane
CCIEAGO:0045177apical part of cell

Gene expression in normal tissue: MGST1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MGST1


DatabasePathway IDPathway Des.
humancycPWY-4061glutathione-mediated detoxification
kegghsa00480Glutathione metabolism - Homo sapiens (human)
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
kegghsa00982Drug metabolism - cytochrome P450 - Homo sapiens (human)
kegghsa00983Drug metabolism - other enzymes - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP408Oxidative Stress
wikipathwaysWP702Metapathway biotransformation Phase I and II
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156580Phase II - Conjugation of compounds
reactomeR-HSA-156590Glutathione conjugation
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-5423646Aflatoxin activation and detoxification
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MGST1

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