MGST1
Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microsomal glutathione S-transferase 1 | MIM:138330 | Ensembl:ENSG00000008394 | HGNC:HGNC:7061 | PA30791 | 12p12.3 |
GO terms in MGST1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004364 | glutathione transferase activity |
| MF | IDA | GO:0004364 | glutathione transferase activity |
| MF | TAS | GO:0004364 | glutathione transferase activity |
| MF | IDA | GO:0004602 | glutathione peroxidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0043295 | glutathione binding |
| MF | IBA | GO:0050220 | prostaglandin-E synthase activity |
| MF | IBA | GO:0050220 | prostaglandin-E synthase activity |
| BP | IBA | GO:0001516 | prostaglandin biosynthetic process |
| BP | IBA | GO:0001516 | prostaglandin biosynthetic process |
| BP | IBA | GO:0006749 | glutathione metabolic process |
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IEA | GO:0010243 | response to organonitrogen compound |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0033327 | Leydig cell differentiation |
| BP | IEA | GO:0042493 | response to drug |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0055114 | oxidation-reduction process |
| BP | IDA | GO:0055114 | oxidation-reduction process |
| BP | ISS | GO:0070207 | protein homotrimerization |
| BP | IDA | GO:0071449 | cellular response to lipid hydroperoxide |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| BP | TAS | GO:1901687 | glutathione derivative biosynthetic process |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | ISS | GO:0005778 | peroxisomal membrane |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0035577 | azurophil granule membrane |
| CC | IEA | GO:0045177 | apical part of cell |
Gene expression in normal tissue: MGST1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MGST1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-4061 | glutathione-mediated detoxification |
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP408 | Oxidative Stress |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156590 | Glutathione conjugation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-5423646 | Aflatoxin activation and detoxification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MGST1
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