MIR17HG
Summary: This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| miR-17-92a-1 cluster host gene | MIM:609415 | Ensembl:ENSG00000215417 | HGNC:HGNC:23564 | PA165505138 | 13q31.3 |
GO terms in MIR17HG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
| BP | ISS | GO:0001782 | B cell homeostasis |
| BP | ISS | GO:0002903 | negative regulation of B cell apoptotic process |
| BP | ISS | GO:0003151 | outflow tract morphogenesis |
| BP | ISS | GO:0003215 | cardiac right ventricle morphogenesis |
| BP | IDA | GO:0014739 | positive regulation of muscle hyperplasia |
| BP | IDA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0035195 | gene silencing by miRNA |
| BP | ISS | GO:0045577 | regulation of B cell differentiation |
| BP | ISS | GO:0050864 | regulation of B cell activation |
| BP | ISS | GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| BP | ISS | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | ISS | GO:0060412 | ventricular septum morphogenesis |
| BP | ISS | GO:0060437 | lung growth |
| CC | IEA | GO:0035068 | micro-ribonucleoprotein complex |
Gene expression in normal tissue: MIR17HG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR17HG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR17HG
CLASSFICATION
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