MIR17HG
Summary: This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:609415 Ensembl IDEnsembl:ENSG00000215417 HGNC IDHGNC:HGNC:23564 PHARMGKB IDPA165505138 Map Location13q31.3 |
GO terms in MIR17HG
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
BP | ISS | GO:0001782 | B cell homeostasis |
BP | ISS | GO:0002903 | negative regulation of B cell apoptotic process |
BP | ISS | GO:0003151 | outflow tract morphogenesis |
BP | ISS | GO:0003215 | cardiac right ventricle morphogenesis |
BP | IDA | GO:0014739 | positive regulation of muscle hyperplasia |
Gene expression in normal tissue: MIR17HG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR17HG
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
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iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR17HG
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |