MIR223
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microRNA 223 | MIM:300694 | Ensembl:ENSG00000284567 | HGNC:HGNC:31603 | PA164722611 | Xq12 |
GO terms in MIR223
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0034260 | negative regulation of GTPase activity |
| BP | IDA | GO:0035195 | gene silencing by miRNA |
| BP | IEA | GO:0035195 | gene silencing by miRNA |
| BP | IDA | GO:0046326 | positive regulation of glucose import |
| BP | IDA | GO:1901342 | regulation of vasculature development |
| BP | IDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IDA | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| BP | IDA | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0035068 | micro-ribonucleoprotein complex |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| MF | IDA | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
Gene expression in normal tissue: MIR223
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR223
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR223
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