MIR34A
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microRNA 34a | MIM:611172 | Ensembl:ENSG00000284357 | HGNC:HGNC:31635 | PA164722675 | 1p36.22|1p36.22 |
GO terms in MIR34A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process |
| BP | IMP | GO:0010942 | positive regulation of cell death |
| BP | IDA | GO:0016525 | negative regulation of angiogenesis |
| BP | IMP | GO:0030336 | negative regulation of cell migration |
| BP | IDA | GO:0035195 | gene silencing by miRNA |
| BP | IEA | GO:0035195 | gene silencing by miRNA |
| BP | IGI | GO:0035195 | gene silencing by miRNA |
| BP | IDA | GO:0051152 | positive regulation of smooth muscle cell differentiation |
| BP | ISS | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IDA | GO:0061044 | negative regulation of vascular wound healing |
| BP | ISS | GO:0071158 | positive regulation of cell cycle arrest |
| BP | IDA | GO:0071456 | cellular response to hypoxia |
| BP | IDA | GO:0071672 | negative regulation of smooth muscle cell chemotaxis |
| BP | IDA | GO:0090281 | negative regulation of calcium ion import |
| BP | IDA | GO:0110058 | positive regulation of blood vessel endothelial cell differentiation |
| BP | IDA | GO:1901985 | positive regulation of protein acetylation |
| BP | IDA | GO:1903671 | negative regulation of sprouting angiogenesis |
| BP | ISS | GO:1903671 | negative regulation of sprouting angiogenesis |
| BP | IDA | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| BP | IDA | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration |
| BP | ISS | GO:1905205 | positive regulation of connective tissue replacement |
| BP | IMP | GO:1905206 | positive regulation of hydrogen peroxide-induced cell death |
| BP | IDA | GO:1905563 | negative regulation of vascular endothelial cell proliferation |
| BP | IDA | GO:2000774 | positive regulation of cellular senescence |
| CC | IEA | GO:0035068 | micro-ribonucleoprotein complex |
| MF | IDA | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing |
Gene expression in normal tissue: MIR34A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MIR34A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | p53downstreampathway | Direct p53 effectors |
| wikipathways | WP2866 | mir34a and TGIF2 in osteoclastogenesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MIR34A
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