MMP14
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| matrix metallopeptidase 14 | MIM:600754 | Ensembl:ENSG00000157227 | HGNC:HGNC:7160 | PA30872 | 14q11.2 |
GO terms in MMP14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016504 | peptidase activator activity |
| MF | IDA | GO:0070006 | metalloaminopeptidase activity |
| MF | TAS | GO:0070006 | metalloaminopeptidase activity |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001541 | ovarian follicle development |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001935 | endothelial cell proliferation |
| BP | IEA | GO:0001958 | endochondral ossification |
| BP | IDA | GO:0006508 | proteolysis |
| BP | TAS | GO:0006508 | proteolysis |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0009725 | response to hormone |
| BP | ISS | GO:0010831 | positive regulation of myotube differentiation |
| BP | IEA | GO:0010952 | positive regulation of peptidase activity |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | TAS | GO:0016485 | protein processing |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | IDA | GO:0030307 | positive regulation of cell growth |
| BP | IEA | GO:0030324 | lung development |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | IEA | GO:0031638 | zymogen activation |
| BP | IEP | GO:0035987 | endodermal cell differentiation |
| BP | IEA | GO:0035988 | chondrocyte proliferation |
| BP | IEA | GO:0043615 | astrocyte cell migration |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | ISS | GO:0045579 | positive regulation of B cell differentiation |
| BP | ISS | GO:0045746 | negative regulation of Notch signaling pathway |
| BP | IEA | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | IEA | GO:0048754 | branching morphogenesis of an epithelial tube |
| BP | IEA | GO:0048771 | tissue remodeling |
| BP | TAS | GO:0048870 | cell motility |
| BP | IEA | GO:0051895 | negative regulation of focal adhesion assembly |
| BP | IEA | GO:0060322 | head development |
| BP | IEA | GO:0097094 | craniofacial suture morphogenesis |
| BP | IEA | GO:1905523 | positive regulation of macrophage migration |
| BP | IEA | GO:1990834 | response to odorant |
| CC | IMP | GO:0005615 | extracellular space |
| CC | IMP | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0031012 | extracellular matrix |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | IEA | GO:0042470 | melanosome |
| CC | IDA | GO:0044354 | macropinosome |
| CC | IDA | GO:0045111 | intermediate filament cytoskeleton |
Gene expression in normal tissue: MMP14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| wikipathways | WP129 | Matrix Metalloproteinases |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| biocarta | reckpathway | inhibition of matrix metalloproteinases |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MMP14
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