MOGAT3
Summary: Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| monoacylglycerol O-acyltransferase 3 | MIM:610184 | Ensembl:ENSG00000106384 | HGNC:HGNC:23249 | PA134959238 | 7q22.1 |
GO terms in MOGAT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006071 | glycerol metabolic process |
| BP | IEA | GO:0019432 | triglyceride biosynthetic process |
| BP | TAS | GO:0019432 | triglyceride biosynthetic process |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | TAS | GO:0003846 | 2-acylglycerol O-acyltransferase activity |
| MF | IEA | GO:0004144 | diacylglycerol O-acyltransferase activity |
Gene expression in normal tissue: MOGAT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MOGAT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-75109 | Triglyceride biosynthesis |
| reactome | R-HSA-8979227 | Triglyceride metabolism |
| wikipathways | WP325 | Triacylglyceride Synthesis |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa04975 | Fat digestion and absorption - Homo sapiens (human) |
| humancyc | TRIGLSYN-PWY | triacylglycerol biosynthesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MOGAT3
CLASSFICATION
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