Summary: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

myelin protein zero like 2MIM:604873Ensembl:ENSG00000149573HGNC:HGNC:3496PA16239614511q23.3

GO terms in MPZL2

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
BPTASGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPTASGO:0009653anatomical structure morphogenesis
CCIEAGO:0016021integral component of membrane

Gene expression in normal tissue: MPZL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MPZL2

DatabasePathway IDPathway Des.
wikipathwaysWP2895Differentiation of white and brown adipocyte

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MPZL2