MTHFD2L
Summary:
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like | MIM:614047 | Ensembl:ENSG00000163738 | HGNC:HGNC:31865 | PA134943916 | 4q13.3 |
GO terms in MTHFD2L
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity |
MF | TAS | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity |
MF | IBA | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
MF | TAS | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
MF | IBA | GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
CC | IEA | GO:0005743 | mitochondrial inner membrane |
CC | TAS | GO:0005759 | mitochondrial matrix |
CC | IBA | GO:0005829 | cytosol |
BP | IEA | GO:0000105 | histidine biosynthetic process |
BP | IEA | GO:0006164 | purine nucleotide biosynthetic process |
BP | IBA | GO:0006730 | one-carbon metabolic process |
BP | IEA | GO:0009086 | methionine biosynthetic process |
BP | IEA | GO:0009256 | 10-formyltetrahydrofolate metabolic process |
BP | IBA | GO:0035999 | tetrahydrofolate interconversion |
BP | IEA | GO:0035999 | tetrahydrofolate interconversion |
BP | IBA | GO:0046653 | tetrahydrofolate metabolic process |
BP | TAS | GO:0046655 | folic acid metabolic process |
BP | IEA | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: MTHFD2L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MTHFD2L
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2525 | Trans-sulfuration and one carbon metabolism |
kegg | hsa00670 | One carbon pool by folate - Homo sapiens (human) |
humancyc | PWY-2201 | folate transformations I |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-196757 | Metabolism of folate and pterines |
reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MTHFD2L