Summary: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008].

mucin 4, cell surface associatedMIM:158372Ensembl:ENSG00000145113HGNC:HGNC:7514PA313193q29

Gene Categories:


GO terms in MUC4

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIEAGO:0007160cell-matrix adhesion
BPTASGO:0016266O-glycan processing
BPIMPGO:0030277maintenance of gastrointestinal epithelium
CCHDAGO:0005615extracellular space
CCTASGO:0005796Golgi lumen
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCNASGO:0031012extracellular matrix
CCHDAGO:0070062extracellular exosome
MFTASGO:0005176ErbB-2 class receptor binding
MFNASGO:0030197extracellular matrix constituent, lubricant activity

Gene expression in normal tissue: MUC4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MUC4

DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083625Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
reactomeR-HSA-5083632Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
reactomeR-HSA-5083636Defective GALNT12 causes colorectal cancer 1 (CRCS1)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5621480Dectin-2 family
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-913709O-linked glycosylation of mucins
reactomeR-HSA-977068Termination of O-glycan biosynthesis

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MUC4