MYCNOS


Summary: This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MYCN opposite strandMIM:605374Ensembl:ENSG00000233718HGNC:HGNC:16911PA1349383382p24.3

Gene Categories:

KINASE

GO terms in MYCNOS


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
BPTASGO:0007275multicellular organism development
BPIMPGO:0008284positive regulation of cell proliferation
BPIMPGO:0031647regulation of protein stability
BPIDAGO:0033673negative regulation of kinase activity
BPIMPGO:0043066negative regulation of apoptotic process
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm

Gene expression in normal tissue: MYCNOS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYCNOS


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYCNOS

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