MYDGF
Summary: The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
myeloid derived growth factor | MIM:606746 | Ensembl:ENSG00000074842 | HGNC:HGNC:16948 | PA29827 | 19p13.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in MYDGF
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
CC | IDA | GO:0005615 | extracellular space |
CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
CC | IEA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
BP | IEA | GO:0001525 | angiogenesis |
BP | ISS | GO:0001934 | positive regulation of protein phosphorylation |
BP | IDA | GO:0001938 | positive regulation of endothelial cell proliferation |
BP | IEA | GO:0006915 | apoptotic process |
BP | ISS | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
BP | ISS | GO:0043066 | negative regulation of apoptotic process |
BP | ISS | GO:0043410 | positive regulation of MAPK cascade |
BP | IDA | GO:0045766 | positive regulation of angiogenesis |
BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
BP | ISS | GO:0051897 | positive regulation of protein kinase B signaling |
Gene expression in normal tissue: MYDGF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYDGF
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP3472 | XBP1(S) activates chaperone genes |
reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
reactome | R-HSA-381070 | IRE1alpha activates chaperones |
reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
reactome | R-HSA-392499 | Metabolism of proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYDGF