MYL12A


Summary: This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
myosin light chain 12AEnsembl:ENSG00000101608HGNC:HGNC:16701PA16472327318p11.31

GO terms in MYL12A


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005829cytosol
CCIEAGO:0016459myosin complex
CCHDAGO:0070062extracellular exosome
BPTASGO:0006936muscle contraction
BPHMPGO:0070527platelet aggregation
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: MYL12A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYL12A


DatabasePathway IDPathway Des.
wikipathwaysWP306Focal Adhesion
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928664Ephrin signaling
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-400685Sema4D in semaphorin signaling
reactomeR-HSA-416572Sema4D induced cell migration and growth-cone collapse
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445355Smooth Muscle Contraction
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5625900RHO GTPases activate CIT
reactomeR-HSA-5627117RHO GTPases Activate ROCKs
reactomeR-HSA-5627123RHO GTPases activate PAKs
reactomeR-HSA-5627123RHO GTPases activate PAKs

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYL12A

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