MYL12B


Summary: The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
myosin light chain 12BMIM:609211Ensembl:ENSG00000118680HGNC:HGNC:29827PA16472327418p11.31

GO terms in MYL12B


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0032036myosin heavy chain binding
CCIEAGO:0001725stress fiber
CCTASGO:0005829cytosol
CCIEAGO:0005903brush border
CCIEAGO:0016460myosin II complex
CCIEAGO:0030018Z disc
CCIEAGO:0045177apical part of cell
CCHDAGO:0070062extracellular exosome
CCIDAGO:0099738cell cortex region
BPTASGO:0006936muscle contraction
BPIEAGO:0008360regulation of cell shape

Gene expression in normal tissue: MYL12B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYL12B


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-400685Sema4D in semaphorin signaling
reactomeR-HSA-416572Sema4D induced cell migration and growth-cone collapse
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445355Smooth Muscle Contraction
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5625900RHO GTPases activate CIT
reactomeR-HSA-5627117RHO GTPases Activate ROCKs
reactomeR-HSA-5627123RHO GTPases activate PAKs
reactomeR-HSA-5627123RHO GTPases activate PAKs
netpathPathway_EGFR1EGFR1
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP306Focal Adhesion

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYL12B

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