MYO1E


Summary: This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
myosin IEMIM:601479Ensembl:ENSG00000157483HGNC:HGNC:7599PA3140115q22.2

GO terms in MYO1E


Term TypeEvidence TypeGO Term IDGO Des.
CCISSGO:0005737cytoplasm
CCIDAGO:0005856cytoskeleton
CCIEAGO:0005903brush border
CCISSGO:0005911cell-cell junction
CCISSGO:0005912adherens junction
CCTASGO:0015629actin cytoskeleton
CCTASGO:0016459myosin complex
CCIDAGO:0045334clathrin-coated endocytic vesicle
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001570vasculogenesis
BPIEAGO:0001701in utero embryonic development
BPISSGO:0003094glomerular filtration
BPIEAGO:0006807nitrogen compound metabolic process
BPIMPGO:0006897endocytosis
BPIEAGO:0007018microtubule-based movement
BPTASGO:0030048actin filament-based movement
BPISSGO:0032836glomerular basement membrane development
BPIEAGO:0035166post-embryonic hemopoiesis
BPIEAGO:0048008platelet-derived growth factor receptor signaling pathway
BPISSGO:0072015glomerular visceral epithelial cell development
MFTASGO:0000146microfilament motor activity
MFTASGO:0003774motor activity
MFIEAGO:0003777microtubule motor activity
MFIPIGO:0005515protein binding
MFIDAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008017microtubule binding
MFIDAGO:0035091phosphatidylinositol binding
MFIDAGO:0042623ATPase activity, coupled
MFIDAGO:0051015actin filament binding

Gene expression in normal tissue: MYO1E

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYO1E


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYO1E

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