MYO1E
Summary: This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin IE | MIM:601479 | Ensembl:ENSG00000157483 | HGNC:HGNC:7599 | PA31401 | 15q22.2 |
GO terms in MYO1E
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0005903 | brush border |
| CC | ISS | GO:0005911 | cell-cell junction |
| CC | ISS | GO:0005912 | adherens junction |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | TAS | GO:0016459 | myosin complex |
| CC | IDA | GO:0045334 | clathrin-coated endocytic vesicle |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | ISS | GO:0003094 | glomerular filtration |
| BP | IEA | GO:0006807 | nitrogen compound metabolic process |
| BP | IMP | GO:0006897 | endocytosis |
| BP | IEA | GO:0007018 | microtubule-based movement |
| BP | TAS | GO:0030048 | actin filament-based movement |
| BP | ISS | GO:0032836 | glomerular basement membrane development |
| BP | IEA | GO:0035166 | post-embryonic hemopoiesis |
| BP | IEA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | ISS | GO:0072015 | glomerular visceral epithelial cell development |
| MF | TAS | GO:0000146 | microfilament motor activity |
| MF | TAS | GO:0003774 | motor activity |
| MF | IEA | GO:0003777 | microtubule motor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0035091 | phosphatidylinositol binding |
| MF | IDA | GO:0042623 | ATPase activity, coupled |
| MF | IDA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: MYO1E
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYO1E
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYO1E
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